Temperature modulation has already been applied for monitoring neural activity, by integrating an external temperature sensor into the neuromodulation equipment. Such sensors, known as the Neurotemperature, can be as small as one millimetre, without relying on standard and bulky external electronics. Such sensors not only give a temperature of the nerve tissue, but also cause a change in their normal biophysical parameters, such as electrical currents in the nerve tissue. Once such temperature modulation is performed, neuroscientists can observe the effect for neural activity monitoring, via the wireless transmission of temperature data.
The thc device provides temperature feedback to the neuro-device. It could thus, for example, indicate if an inflection of a neural activity level is a result of a temperature fluctuation or a further input from the thc device itself. It could therefore be used to dynamically control neural activity to fine-tune control over neural behaviour. For example, increasing the temperature could lead to shorter output pulses, and also trigger the onset of neural activity encoding. Once the appropriate frequency has been reached, switching back to an amplitude modulation, such as frequency modulation, could influence the dynamics of neural activity over long time scales.
Previous studies have also shown that a temperature increase may slow down nerve processing and promote neural activity encoding. This is likely to be due to a feedback effect